Publications

Selected publications

• Tokizane, K., Brace, C. S., & Imai, S. I. (2024). DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication. Cell Metabolism, 36(2), 377-392.
• Unno, J., Mills, K. F., Ogura, T., Nishimura, M., & Imai, S. I. (2024). Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS). npj Aging, 10(1), 2.
• Johnson, S., Yoshioka, K., Brace, C. S., & Imai, S. I. (2023). Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus. npj Aging, 9(1), 1.
• Ito, N., Takatsu, A., Ito, H., Koike, Y., Yoshioka, K., Kamei, Y., & Imai, S. I. (2022). Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging. Cell Reports, 40(4).
• Lananna, B. V. and Imai, S. (2021) Friends and foes: Extracellular vesicles in aging and rejuvenation. FASEB bioAdvances 3(10).
• Yoshino, M., J. Yoshino, B. D. Kayser, G. J. Patti, M. P. Franczyk, K. F. Mills, M. Sindelar, T. Pietka, B. W. Patterson, S.-I. Imai and S. Klein. (2021) Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. SCIENCE, Vol 372, Issue 6547
• Tokizane, K. and S.-i. Imai. (2021) NAD+ oscillation and hypothalamic neuronal functions. F1000Prime Rep 10(42).
• Yoshida, M., Satoh, A., Lin, J.B., Mills, K.F., Sasaki, Y., Rensing, N., Wong, M., Apte, R.S., and Imai, S. (2019) Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice. Cell Metab., 30: 329-342.
• Grozio, A., Mills, K.F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H.C., Cunningham, R., Sasaki, Y., Migaud, M.E.,Imai S.I., et al. (2019) Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab1: 47-57. PMCID: PMC6530925
• Johnson, S., Wozniak, D.F., and Imai, S. (2018) CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves. NPJ Aging Mech Dis4, 10. doi: 10.1038/s41514-018-0029-z.PMCID: PMC6224504
• Yoshino, J., Baur, J.A., and Imai, S. (2018) NAD⁺Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab 27: 513-528. PMCID: PMC5842119
• Satoh, A., Imai, S., and Guarente, L.P. (2017)

  The brain, sirtuins, and ageing. Rev. Neurosci.  18: 362-374. doi: 10.1038/nrn.2017.42.

• Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Miguard, M. E., Apte, R. S., Uchida, K., Yoshino, J.*, and Imai, S.* (2016) Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice.  Cell Metab.  24: 795-806.  (*Co-correspondance)
• Lin, J. B.§, Kubota, S.§, Ban, N., Yoshida, M., Santeford, A., Sene, A., Nakamura, R., Zapata, N., Kubota, M., Tsubota, K., Yoshino, J., Imai, S.*, and Apte, R. S.* (2016)  NAMPT-mediated NAD⁺biosynthesis is essential for vision in mice.  Cell Rep.  17: 69-85.  (§equally contributing authors; *co-correspondence). PMCID: PMC5104206
• Stromsdorfer, K. L.*, Yamaguchi, S.*, Yoon, M. J.*, Moseley, A. C., Franczyk, M. P., Kelly, S. C., Qi, N., Imai, S., and Yoshino, J.  (2016) NAMPT-mediated NAD⁺biosynthesis in adipocytes regulates adipose tissue function and multi-organ insulin sensitivity in mice.  Cell Rep.  16: 1851-1860.  (*equally contributing authors)  PMCID: PMC5094180
• Imai, S.  (2016)  The NAD World 2.0: The Importance of the Inter-Tissue Communication Mediated by NAMPT/NAD⁺/SIRT1 in Mammalian Aging/Longevity Control.  npj Systems Biology and Applications.  doi:10.1038/npjsba.2016.18  PMCID: PMC5516857
• Imai, S. and Guarente, L.  (2016) It takes two to tango: NAD⁺and sirtuins in aging/longevity control.  npj Aging and Mechanisms of Disease.  doi:10.1038/npjamd.2016.17 PMCID: PMC5514996
• Yoon, M. J., Yoshida, M., Johnson, S., Takikawa, A., Usui, I., Tobe, K., Nakagawa, T., Yoshino, J., and Imai, S.  (2015)  SIRT1-mediated eNAMPT secretion from adipose tissue regulates hypothalamic NAD⁺ and function in mice.  Cell Metab.  21: 706-717.  PMCID: PMC4426056
• Satoh, A., Brace, C. S., Rensing, N., and Imai, S.  (2015)  Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity. Aging Cell  14: 209-218.  PMCID: PMC4364833
• Satoh, A. and Imai, S.  (2014)  Systemic regulatory mechanisms of mammalian aging and longevity by brain sirtuins.  Nat. Commun.  5: 4211. doi: 10.1038/ncomms5211.
• Stein, L. R. and Imai, S.  (2014)  Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging(accompanied with a featured preview article).  EMBO J. 33: 1321-1340.  PMCID: PMC4194122
• Stein, L. R., Wozniak, D. F., Dearborn, J. T., Kutabo, S., Apte, R. S., Izumi, Y., Zorumski, C. F. and Imai S. (2014) Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function (A featured article). J. Neurosci.  34: 5800-5815.  PMCID: PMC3996209
• Satoh, A., Brace, C. S., Rensing, N., Clifton, P., Wozniak, D. F., Herzog, E. G., Yamada, K. A., and Imai, S.  (2013)  Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH (Among the most-downloaded articles from Cell Press in September 2013).  Cell Metab. 18: 416-430.  PMCID: PMC3794712

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