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Research Summary

We are interested in understanding the systemic regulation of aging and longevity in mammals and translating that knowledge into effective anti-aging interventions that could make our lives as healthy and productive as possible (“productive aging”).  We have so far identified three tissues critical to our understanding of this regulation: the hypothalamus as the control center, skeletal muscle as an effector, and adipose tissue as a modulator. By applying all available analytical tools, we continue to integrate our findings into a comprehensive concept of mammalian aging and longevity control, we call the “NAD World”. Please visit our research page to learn more about our current projects!

A scheme of the NAD World 2.0, the inter-tissue regulatory network for mammalian aging and longevity control

Positions Available

We are actively recruiting graduate students, undergraduate students, and postdoctoral fellows!

Please feel free to contact Dr. Shin-ichiro Imai at imaishin{at}, if you are interested or have any questions.

Temporary Lab Location

We are currently at a temporary lab location (1902 South Building) waiting for our lab space renovation to be finished. We expect to move back to McDonnell Sciences 3rd floor within the year.